Clarification of the C-35 stereochemistries of dinophysistoxin-1 and dinophysistoxin-2 and its consequences for binding to protein phosphatase.

@article{Larsen2007ClarificationOT,
  title={Clarification of the C-35 stereochemistries of dinophysistoxin-1 and dinophysistoxin-2 and its consequences for binding to protein phosphatase.},
  author={K. J. Larsen and Dirk Petersen and Alistair L. Wilkins and Ingunn A Samdal and Morten Renslo Sandvik and Thomas Rundberget and David C Goldstone and Vickery L Arcus and Peter Hovgaard and Frode Rise and Nils Rehmann and Philipp Hess and Christopher O Miles},
  journal={Chemical research in toxicology},
  year={2007},
  volume={20 6},
  pages={
          868-75
        }
}
Okadaic acid analogues are well known as protein phosphatase inhibitors and occur naturally in marine shellfish feeding on dinoflagellates of the genus Dinophysis, leading to diarrhetic shellfish poisoning of shellfish consumers. Knowledge of the correct structures for these toxins is important in understanding their toxicology, biochemistry, and biosynthesis. We have performed extensive NMR analyses on okadaic acid (1), dinophysistoxin-1 (DTX-1), and dinophysistoxin-2 (DTX-2) obtained from… CONTINUE READING

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