Clarence Cook Little (1888–1971): The Genetic Basis of Transplant Immunology

  title={Clarence Cook Little (1888–1971): The Genetic Basis of Transplant Immunology},
  author={Hugh Auchincloss and Henry J. Winn},
  journal={American Journal of Transplantation},
Clarence Cook Little was born just outside of Boston in 1888 into an old Boston family descended from Paul Revere (1,2). He became the captain of the track team at Harvard College, received his PhD from Harvard University, and then joined its faculty. His first (of 15) publications in Science appeared when he was 21 years old. He had been hired (and resigned) as the president of two important universities by the age of 40. His passion was genetics and his ambition was to find the genetic causes… 
2 Citations

Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance

PD-L1 expression on A20 leukemia tumor cells modulates CD8 T-cell-mediated responses to tumor-specific antigens but does not contribute to inhibit NK cell-mediated hybrid resistance, which correlates with the inability to detect PD- 1 expression on NK cells neither under steady-state conditions nor under inflammatory conditions.



The genetics of tissue transplantation in mammals.

This paper has its justification in the fact that the subject of the genetics of tissue transplantation is likely to become in the not distant future of far greater general importance than it is at present and much of the published work in this field has been done by medical men or institutions, and has appeared in medical journals.

The inheritance of susceptibility to implants of splenic tissue in mice. 1. Japanese waltzing mice, albinos, and their F1 generation hybrids

Results are obtained which show that the distinctions between “homio,”“syngenesio” and “auto” transplantations are only relative and may be delibrately broken down by picking animals of certain definite genetic constitutions for experirnentation.

Studies on the Genetic and Antigenic Basis of Tumour Transplantation. Linkage between a Histocompatibility Gene and 'Fused' in Mice

Serological tests are preferable to tumour inoculation in the identification of genotypes and it is suggested that the dba gene is an allele of the above and should be called $H_{2}{}^{d}$.

George Snell's first foray into the unexplored territory of the major histocompatibility complex.

THE expression “ x number years ago” is a moving target. Right now it is 50 years ago, but next year it will be more than 50 and a year later more again. Historians avoid this relativity by agreeing

A Cross Involving Four Pairs of Mendelian Characters in Mice

The present experiment was planned as a control upon more detailed work being carried on at the Bussey Institution, as demonstrating from a single cross the existence of four independent pairs of Mendelian characters in the color inheritance of mice.


The author aims to show with what complete accuracy problems in the relation of heredity to disease can be solved with complete accuracy in this work.

The genetics of tumor transplantation.

Little, cancer, and inbred mice

  • Genetics
  • 2002

Further experimental studies on inheritance of susceptibility to a transplantable tumor of Japanese waltzing mice

  • J Med Res
  • 1916