Clarence Cook Little (1888–1971): The Genetic Basis of Transplant Immunology

@article{Auchincloss2004ClarenceCL,
  title={Clarence Cook Little (1888–1971): The Genetic Basis of Transplant Immunology},
  author={Hugh Auchincloss and Henry J. Winn},
  journal={American Journal of Transplantation},
  year={2004},
  volume={4}
}
Clarence Cook Little was born just outside of Boston in 1888 into an old Boston family descended from Paul Revere (1,2). He became the captain of the track team at Harvard College, received his PhD from Harvard University, and then joined its faculty. His first (of 15) publications in Science appeared when he was 21 years old. He had been hired (and resigned) as the president of two important universities by the age of 40. His passion was genetics and his ambition was to find the genetic causes… 
2 Citations

Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance

PD-L1 expression on A20 leukemia tumor cells modulates CD8 T-cell-mediated responses to tumor-specific antigens but does not contribute to inhibit NK cell-mediated hybrid resistance, which correlates with the inability to detect PD- 1 expression on NK cells neither under steady-state conditions nor under inflammatory conditions.

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