Cladribine for the treatment of hematologic malignancies.

Abstract

The mechanism of action, pharmacokinetics, efficacy, adverse effects, storage, dosage and administration, and cost of cladribine are reviewed. Cladribine (2-chloro-2'-deoxyadenosine) is a synthetic purine nucleoside developed for the treatment of hematologic malignancies. It appears that cladribine interferes with lymphocyte proliferation by inhibiting DNA… (More)

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@article{Baltz1993CladribineFT, title={Cladribine for the treatment of hematologic malignancies.}, author={J K Baltz and Michael J Montello}, journal={Clinical pharmacy}, year={1993}, volume={12 11}, pages={805-13; quiz 860-2} }