ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion.

@article{Supanchart2014ClC7EL,
  title={ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion.},
  author={Chayarop Supanchart and Lena Wartosch and Claire Schlack and Jirko K{\"u}hnisch and Dieter Felsenberg and Jens C. Fuhrmann and M-C de Vernejoul and Thomas J Jentsch and Uwe Kornak},
  journal={Bone},
  year={2014},
  volume={58},
  pages={92-102}
}
Mutations in the 2Cl(-)/1H(+)-exchanger ClC-7 impair osteoclast function and cause different types of osteoclast-rich osteopetrosis. However, it is unknown to what extent ClC-7 function has to be reduced to become rate-limiting for bone resorption. In osteoclasts from osteopetrosis patients expression of the mutated ClC-7 protein did not correlate with disease severity and resorption impairment. Therefore, a series of transgenic mice expressing ClC-7 in osteoclasts at different levels was… CONTINUE READING
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