ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.

@article{Harachikuma2005ClC3CC,
  title={ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.},
  author={Mariko Hara-chikuma and Baoxue Yang and N. D. Sonawane and Sei Sasaki and Shinichi Uchida and Alan S. Verkman},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 2},
  pages={1241-7}
}
We investigated the involvement of ClC-3 chloride channels in endosomal acidification by measurement of endosomal pH and chloride concentration [Cl-] in control versus ClC-3-deficient hepatocytes and in control versus ClC-3-transfected Chinese hamster ovary cells. Endosomes were labeled with pH or [Cl-]-sensing fluorescent transferrin (Tf), which targets to… CONTINUE READING