ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization.

@article{Cataln2002ClC2IG,
  title={ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization.},
  author={Marcelo Catal{\'a}n and Isabel Cornejo and Carlos D. Figueroa and Mar{\'i}a Isabel Niemeyer and Francisco V Sep{\'u}lveda and L. Pablo Cid},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={283 4},
  pages={G1004-13}
}
The principal function of the colon in fluid homeostasis is the absorption of NaCl and water. Apical membrane Na(+) channels, Na(+)/H(+) and Cl(-)/HCO exchangers, have all been postulated to mediate NaCl entry into colonocytes. The identity of the basolateral exit pathway for Cl(-) is unknown. We have previously demonstrated the presence of the ClC-2 transcript in the guinea pig intestine. Now we explore in more detail, the tissue and cellular distribution of chloride channel ClC-2 in the… CONTINUE READING
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