ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum.

@article{Moeser2004ClC2CS,
  title={ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum.},
  author={A J Moeser and Melissa M. Haskell and Donnie E Shifflett and D Wayne Little and Bruce D. Schultz and Anthony T Blikslager},
  journal={Gastroenterology},
  year={2004},
  volume={127 3},
  pages={802-15}
}
BACKGROUND & AIMS Ischemia results in the breakdown of the intestinal barrier, predisposing patients to sepsis and multiple organ failure. Prostaglandins play a critical role in mediating recovery of barrier function in ischemia-injured intestine through a mechanism involving stimulation of Cl - secretion. In the present study, we investigated the contributory role of individual Cl - channels in the recovery of barrier function in ischemia-injured porcine ileum. METHODS Ischemia-injured… CONTINUE READING