Cl- -dependent upregulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3.

@article{Ueo2007ClU,
  title={Cl- -dependent upregulation of human organic anion transporters: different effects on transport kinetics between hOAT1 and hOAT3.},
  author={Harumasa Ueo and Hideyuki Motohashi and Toshiya Katsura and Ken-ichi Inui},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 1},
  pages={F391-7}
}
Chloride ion has a stimulatory effect on the transport of organic anions across renal basolateral membranes. However, the exact mechanisms at molecular levels have been unclear as of yet. Human organic anion transporters hOAT1 and hOAT3 play important roles in renal basolateral membranes. In this study, the effects of Cl(-) on the activities of these transporters were evaluated by using HEK293 cells stably expressing hOAT1 or hOAT3 (HEK-hOAT1 or HEK-hOAT3). The uptake of p-[(14)C]aminohippurate… CONTINUE READING