Cl- channel blockers inhibit transition of quiescent (G0) fibroblasts into the cell cycle.

@article{Zheng2003ClCB,
  title={Cl- channel blockers inhibit transition of quiescent (G0) fibroblasts into the cell cycle.},
  author={Ya-juan Zheng and Tetsushi Furukawa and Kimitaka Tajimi and Naofumi Inagaki},
  journal={Journal of cellular physiology},
  year={2003},
  volume={194 3},
  pages={
          376-83
        }
}
Modulation of ion permeability during the cell cycle is one of the key events in cell cycle progression. We have compared the effects of K+ and Cl- channel blockers on the cell cycle in synchronous and asynchronous NIH3T3 cells. The Cl- channel blocker 5-N-2-(3-phenylpropylamino) benzoic acid (NPPB; 0.2 mM) inhibited entry into S phase in synchronous cells but not in asynchronous cells, while the K+ channel blocker 4-aminopyridine (4-AP) showed similar inhibitory effects in both conditions. In… CONTINUE READING
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