Cl- channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'.

@article{Myssina2004ClCB,
  title={Cl- channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte 'apoptosis'.},
  author={Svetlana Myssina and Philipp A. Lang and Daniela S. Kempe and Stefanie Kaiser and Stephan M Huber and Thomas Wieder and Florian Lang},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2004},
  volume={14 4-6},
  pages={241-8}
}
Exposure to Ca2+ ionophore ionomycin, osmotic shock, oxidative stress and glucose depletion trigger cell shrinkage and scramblase-mediated phosphatidylserine exposure at the outer leaflet of the erythrocyte cell membrane. The effects are partially due to activation of GARDOS channels and subsequent cellular K+ loss leading not only to cell shrinkage but also participating in the triggering of erythrocyte scramblase. As conductive loss of K+ would depend on the parallel loss of anions we… CONTINUE READING

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