Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.

@article{Westbrook2007Cks1RC,
  title={Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.},
  author={Louise Westbrook and Marina Manuvakhova and Francis G. Kern and Norman R. Estes and Harish N Ramanathan and Jaideep V. Thottassery},
  journal={Cancer research},
  year={2007},
  volume={67 23},
  pages={11393-401}
}
Cks1, a small protein whose expression is strongly associated with aggressive breast tumors, is a component of cyclin-cdk complexes, as well as the SCF(Skp2) ubiquitin ligase. In these studies, we explored its roles in estrogen receptor-positive breast tumor cells. When exposed to the antiestrogen ICI 182780, these cells accumulate in G(1) by reducing the expression of Cks1, and increasing the levels of p130/Rb2, a cdk2 inhibitor and SCF(Skp2) target. Heregulin beta1 or estradiol abrogate… CONTINUE READING

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