Citrus flavanones enhance carotenoid uptake by intestinal Caco-2 cells.

@article{Claudie2013CitrusFE,
  title={Citrus flavanones enhance carotenoid uptake by intestinal Caco-2 cells.},
  author={Dhuique-mayer Claudie and During Alexandrine and Caporiccio Bertrand and Tourniaire Franck and Amiot-Carlin Marie-Josephe},
  journal={Food \& function},
  year={2013},
  volume={4 11},
  pages={
          1625-31
        }
}
The health benefit of a diet rich in fruits and vegetables could be attributed to the presence of a large diversity of phytochemicals, including carotenoids. Bioactivities of carotenoids greatly depend on their bioavailability that could be modulated by the presence of other dietary constituents. Because citrus juices contain diverse antioxidant phytochemicals, the effects of flavonoids and ascorbic acid on intestinal carotenoid uptake were investigated. Experiments were conducted by using a… 

Figures from this paper

Hesperetin and Hesperidin Improved β-Carotene Incorporation Efficiency, Intestinal Cell Uptake, and Retinoid Concentrations in Tissues.

The increases in scavenger receptor class B type I (SR-BI) expression promoted by citrus flavanones played an important role in Bc cellular absorption in the Caco-2 cell model and suggested that the incorporation efficiency into micelles was the main step governing carotenoid bioavailability.

Iron, Catechin, and Ferulic Acid Inhibit Cellular Uptake of β-Carotene by Reducing Micellization.

The large reductions in β-carotene micellization observed in vitro warrant further investigation in humans using model green leafy vegetable systems to elucidate their relevance under real-life conditions.

Citrus Flavanones Enhance β-Carotene Uptake in Vitro Experiment Using Caco-2 Cell: Structure-Activity Relationship and Molecular Mechanisms.

The results showed that multiple hydroxyl groups had the lowest promoting effect, and O-Glycosylation at C7 of the A ring led to the greatest promoting effect on Bc absorption.

Interaction between Flavonoids and Carotenoids on Ameliorating Oxidative Stress and Cellular Uptake in Different Cells

A diet rich in both flavonoids and lycopene possesses a great antioxidant activity, especially if a higher amount of flavonoid is included.

Polyphenols from artichoke heads (Cynara cardunculus (L.) subsp. scolymus Hayek): in vitro bio-accessibility, intestinal uptake and bioavailability.

In conclusion, the utilized in vitro models, although not fully responding to the morphological and physiological features of human in vivo conditions, could be a useful tool for investigating mechanistic effects of polyphenols released from the food matrix.

References

SHOWING 1-10 OF 47 REFERENCES

β-Cryptoxanthin from Citrus juices: assessment of bioaccessibility using an in vitro digestion/Caco-2 cell culture model

Bioaccessibility was investigated by measuring the transfer of carotenoids from different citrus juices into micelles using an in vitro digestion system and preferential uptake by Caco-2 cells of [ beta]-carotene and free [beta]-CX compared with the two esterified forms showed.

Impaired uptake of β-carotene by Caco-2 human intestinal cells in the presence of iron

Iron provided in physiological amounts inhibited the uptake of β-carotene in the in vitro Caco-2 cell system.

Beta-cryptoxanthin from citrus juices: assessment of bioaccessibility using an in vitro digestion/Caco-2 cell culture model.

Bioaccessibility was investigated by measuring the transfer of carotenoids from different citrus juices into micelles using an in vitro digestion system and preferential uptake by Caco-2 cells of beta-carotene and free beta-CX compared with the two esterified forms showed.

Lysophosphatidylcholine enhances carotenoid uptake from mixed micelles by Caco-2 human intestinal cells.

Results suggest that pancreatic PLA2 and lysoPC are important in regulating the absorption of carotenoids in the digestive tract and support a simple diffusion mechanism for carotanoid absorption by the intestinal epithelium.

Biological actions of carotenoids 1

  • A. BendichJ. Olson
  • Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1989
In epidemiological studies, the intake of carotenoid‐rich fruits and vegetables has been correlated with protection from some forms of cancer, particularly lung cancer, and serum β‐carotene levels have been associated with a decreased chance of developing lung cancer.

Carotenoid uptake and secretion by CaCo-2 cells: beta-carotene isomer selectivity and carotenoid interactions.

The present results indicate that beta-C conformation plays a major role in its intestinal absorption and that cis isomer discrimination is at the levels of cellular uptake and incorporation into chylomicrons, and suggest that carotenoid uptake by intestinal cells is a facilitated process.

Some dietary fibers reduce the absorption of carotenoids in women.

It is concluded that the bioavailability of beta-carotene, lycopene and lutein given within a mixed supplement is markedly reduced by different kinds of dietary fiber.

Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers

Inhibition studies showed that efflux of hesperetin conjugates to the apical side involved active transport, which from the pattern of inhibition appeared to involve mainly BCRP, and showed that B CRP-mediated transport could be a limiting step for he Speretin bioavailability.