Citrus bergamia Juice Extract Attenuates β-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways

@inproceedings{Curr2016CitrusBJ,
  title={Citrus bergamia Juice Extract Attenuates β-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways},
  author={Monica Curr{\`o} and Roberto Risitano and Nadia Ferlazzo and Santa Cirmi and Chiara Gangemi and Daniela Caccamo and Riccardo Ientile and Michele Navarra},
  booktitle={Scientific reports},
  year={2016}
}
Flavonoids have been shown to be effective in protecting against age-related cognitive and motor decline in both in vitro and in vivo models. Recently, a flavonoid-rich extract of Citrus bergamia juice (BJe) has been shown to display anti-oxidant and anti-inflammatory properties against LPS-induced activation of human THP-1 monocytes. In the light of these observations, we wondered whether BJe may be beneficial against neuroinflammatory processes, such as those observed in Alzheimer's disease… CONTINUE READING