Citrus aurantium, an Ingredient of Dietary Supplements Marketed for Weight Loss: Current Status of Clinical and Basic Research

@article{FughBerman2004CitrusAA,
  title={Citrus aurantium, an Ingredient of Dietary Supplements Marketed for Weight Loss: Current Status of Clinical and Basic Research},
  author={Adriane Fugh-Berman and Adam Myers},
  journal={Experimental Biology and Medicine},
  year={2004},
  volume={229},
  pages={698 - 704}
}
Seville orange (Citrus aurantium) extracts are being marketed as a safe alternative to ephedra in herbal weight-loss products, but C. aurantium may also have the potential to cause adverse health effects. C. aurantium contains synephrine (oxedrine), which is structurally similar to epinephrine. Although no adverse events have been associated with ingestion of C. aurantium products thus far, synephrine increases blood pressure in humans and other species, and has the potential to increase… Expand
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References

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Seville (sour) Orange Juice: Synephrine Content and Cardiovascular Effects in Normotensive Adults
TLDR
Individuals with severe hypertension, tachyarrhythmias, and narrow‐angle glaucoma and monoamine oxidase inhibitor recipients should avoid SOJ consumption and persons taking decongestant‐containing cold preparations should also refrain from SOJ intake. Expand
Effects of Citrus aurantium extract, caffeine, and St. John's Wort on body fat loss, lipid levels, and mood states in overweight healthy adults
TLDR
It was concluded that the combination of C aurantium extract, caffeine, and St. John's Wort is safe and effective when combined with mild caloric restriction and exercise for promoting both body weight and fat loss in healthy overweight adults. Expand
Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids
TLDR
An independent review of reports of adverse events related to the use of supplements that contained ephedra alkaloids was conducted to assess causation and to estimate the level of risk the Use of these supplements poses to consumers. Expand
Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC.
The purpose of this study was to set up a HPLC method to separate adrenergic amines (dl-octopamine, dl-synephrine and tyramine) and to determine their content in fruits, extracts and herbal productsExpand
Acute intoxication of cyclosporin caused by coadministration of decoctions of the fruits of Citrus aurantium and the Pericarps of Citrus grandis.
TLDR
The results indicated that the coadministration of CAF and CGP significantly increased the Cmax and AUC of cyclosporin by 64% and 79%, respectively, which indicates an interaction of Citrus compounds with a commonly used drug. Expand
Herb-drug interactions
TLDR
Patients should caution patients against mixing herbs and pharmaceutical drugs, as many reports of herb-drug interactions are sketchy and lack laboratory analysis of suspect preparations. Expand
Anti-shock effects of synthetic effective compositions of fructus aurantii immaturus. Experimental study and clinical observation.
TLDR
The anti-shock effective compositions in FAI have been proved to be synephrine and N-methyltyrosamine, which has shown a more stable property, less side-effects and better clinical results than nat-FAI. Expand
The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein.
TLDR
It is confirmed that grapefruit and seville orange juice are long-lasting and perhaps irreversible inhibitors of gut CYP3A/P-glycoprotein, and a novel method of phenotyping for CYP2D6, CYP 3A and P- glycoprotein using DM as a probe is presented. Expand
Herbal drugs and phytopharmaceuticals
TLDR
This book contains detailed monographs on 181 medicinal herbs common in pharmaceutical practice and provides references to pharmacopoeial monographs, sources, synonyms, constituents, indications, side effects, preparation of a tea, commercially available phytomedicines, regulatory status, authentication using macroscopical, microscopICAL, and chromatographic techniques. Expand
Effect of Seville Orange Juice and Grapefruit Juice on Indinavir Pharmacokinetics
TLDR
Modulation of intestinal CYP3A4 by grapefruit juice and Seville orange juice did not alter the systemic availability of indinavir and the contribution of presystemic metabolism toIndinavir interpatient variability appears to be small. Expand
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