Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resection.

@article{Osowska2004CitrullineIA,
  title={Citrulline increases arginine pools and restores nitrogen balance after massive intestinal resection.},
  author={Sylwia Osowska and Christophe Moinard and Nathalie Neveux and C{\'e}cile Lo{\"i} and Luc A Cynober},
  journal={Gut},
  year={2004},
  volume={53 12},
  pages={1781-6}
}
OBJECTIVE Arginine supplementation seems logical in situations where this amino acid becomes essential, for example after massive intestinal resection. Arginine is taken up and metabolised by the liver to a large extent and its supplementation is potentially unsafe. Citrulline is not captured by the liver and passes freely to the kidneys where it is metabolised to arginine, and so is a good candidate to generate arginine and thereby improve nutritional status. METHODS Twenty four rats were… CONTINUE READING

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