Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage.

@article{Lutgens2003CitrullineAP,
  title={Citrulline: a physiologic marker enabling quantitation and monitoring of epithelial radiation-induced small bowel damage.},
  author={L. C. H. W. Lutgens and Nicolaas E P Deutz and John Gueulette and Jack P. M. Cleutjens and Martijn P.F. Berger and Bradly G. Wouters and Maarten F. von Meyenfeldt and Philippe Lambin},
  journal={International journal of radiation oncology, biology, physics},
  year={2003},
  volume={57 4},
  pages={1067-74}
}
PURPOSE Small bowel irradiation results in epithelial cell loss and consequently impairs function and metabolism. We investigated whether citrulline, a metabolic end product of small bowel enterocytes, can be used for quantifying radiation-induced epithelial cell loss. METHODS AND MATERIALS NMRI mice were subjected to single-dose whole body irradiation (WBI). The time course of citrullinemia was assessed up to 11 days after WBI. A dose-response relationship was determined at 84 h after WBI… CONTINUE READING