Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis.

@article{Raijmakers2005CitrullinationOC,
  title={Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis.},
  author={R. A. P. Raijmakers and Judith H P Vogelzangs and John Ludovic Croxford and Pieter Wesseling and Walther J. van Venrooij and Ger J. M. Pruijn},
  journal={The Journal of comparative neurology},
  year={2005},
  volume={486 3},
  pages={243-53}
}
Immunization of mammals with central nervous system (CNS)-derived proteins or peptides induces experimental autoimmune encephalomyelitis (EAE), a disease resembling the human autoimmune disease multiple sclerosis (MS). Both diseases are accompanied by destruction of a part of the of the myelin sheaths, which surround neurites in the CNS. Previous studies in MS have described alterations in the citrullination of myelin basic protein, one of the main protein constituents of the myelin sheath… CONTINUE READING

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