Citrullination in the periodontium—a possible link between periodontitis and rheumatoid arthritis

@article{Laugisch2015CitrullinationIT,
  title={Citrullination in the periodontium—a possible link between periodontitis and rheumatoid arthritis},
  author={Oliver Laugisch and Alicia Wong and Aneta Sroka and Tomasz Kantyka and Joanna Koziel and Klaus W. Neuhaus and Anton Sculean and Patrick J W Venables and Jan Potempa and Burkhard M{\"o}ller and Sigrun Eick},
  journal={Clinical Oral Investigations},
  year={2015},
  volume={20},
  pages={675-683}
}
The aim of the present study was to assess human and bacterial peptidylarginine deiminase (PAD) activity in the gingival crevicular fluid (GCF) in the context of serum levels of antibodies against citrullinated epitopes in rheumatoid arthritis and periodontitis. Human PAD and Porphyromonas gingivalis-derived enzyme (PPAD) activities were measured in the GCF of 52 rheumatoid arthritis (RA) patients (48 with periodontitis and 4 without) and 44 non-RA controls (28 with periodontitis and 16 without… CONTINUE READING
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