Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.

  title={Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.},
  author={Dieter Rondas and Inne Cr{\`e}vecoeur and Wannes D'Hertog and Gabriela Bomfim Ferreira and An Staes and Abhishek D Garg and Decio L. Eizirik and Patrizia Agostinis and Kris Gevaert and Lut Overbergh and Chantal Mathieu},
  volume={64 2},
Posttranslational modifications of self-proteins play a substantial role in the initiation or propagation of the autoimmune attack in several autoimmune diseases, but their contribution to type 1 diabetes is only recently emerging. In the current study, we demonstrate that inflammatory stress, induced by the cytokines interleukin-1β and interferon-γ, leads to citrullination of GRP78 in β-cells. This is coupled with translocation of this endoplasmic reticulum chaperone to the β-cell plasma… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 30 extracted citations

Metabolic Determinants of Impaired Pulmonary Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association • 2018


Publications referenced by this paper.

Similar Papers

Loading similar papers…