Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA

@article{Ahmed2011CitronKR,
  title={Citron kinase regulates axon growth through a pathway that converges on cofilin downstream of RhoA},
  author={Zubair Ahmed and Michael R. Douglas and Martin L Read and Martin F. Berry and Ann Logan},
  journal={Neurobiology of Disease},
  year={2011},
  volume={41},
  pages={421-429}
}
Axon regeneration in the adult central nervous system (CNS) is prevented by inhibitory molecules present in myelin, which bind to a receptor complex that leads to downstream RhoGTP activation and axon growth cone collapse. Here, we compared expression of Citron kinase (Citron-K), a target molecule of RhoGTP in non-regenerating dorsal root ganglion neurons (DRGN) after dorsal column (DC) injury, and in regenerating DRGN after either sciatic nerve (SN) injury or preconditioning SN+DC lesion… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

RHO Gtpases and the Actin Cytoskeleton

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL