Citric acid production by a novel Aspergillus niger isolate: II. Optimization of process parameters through statistical experimental designs.

@article{Lotfy2007CitricAP,
  title={Citric acid production by a novel Aspergillus niger isolate: II. Optimization of process parameters through statistical experimental designs.},
  author={Walid A Lotfy and Khaled M. Ghanem and Ehab R. El-Helow},
  journal={Bioresource technology},
  year={2007},
  volume={98 18},
  pages={3470-7}
}
In this work, sequential optimization strategy, based on statistical designs, was employed to enhance the production of citric acid in submerged culture. For screening of fermentation medium composition significantly influencing citric acid production, the two-level Plackett-Burman design was used. Under our experimental conditions, beet molasses and corn steep liquor were found to be the major factors of the acid production. A near optimum medium formulation was obtained using this method with… CONTINUE READING

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