Citric acid as a pH-modifying additive in an extended release pellet formulation containing a weakly basic drug.

@article{Ploen2009CitricAA,
  title={Citric acid as a pH-modifying additive in an extended release pellet formulation containing a weakly basic drug.},
  author={Jan Ploen and Jens Andersch and Michael Heschel and Claudia Sabine Leopold},
  journal={Drug development and industrial pharmacy},
  year={2009},
  volume={35 10},
  pages={
          1210-8
        }
}
BACKGROUND An extended release pellet formulation (ACES(R)) of the weakly basic drug propiverine was developed with spheronized citric acid crystals as starter cores. METHOD Coated pellets, consisting of several layers of functional coatings, were manufactured by fluid bed coating. Different coating levels were examined with regard to their effect on drug release. Release profiles from the formulations with or without pH modifier and the free base as well as the hydrochloride salt of the… CONTINUE READING

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