Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: Towards development of safe tunable intravenous lipid nanocarriers.

@article{Wibroe2015CitremMI,
  title={Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: Towards development of safe tunable intravenous lipid nanocarriers.},
  author={Peter Popp Wibroe and Intan D Mat Azmi and Christa Nilsson and Anan Yaghmur and Seyed Moein Moghimi},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2015},
  volume={11 8},
  pages={1909-14}
}
UNLABELLED Lyotropic non-lamellar liquid crystalline (LLC) aqueous nanodispersions hold a great promise in drug solubilization and delivery, but these nanosystems often induce severe hemolysis and complement activation, which limit their applications for safe intravenous administration. Here, we engineer and characterize LLC aqueous nanodispersions from a binary lipid mixture consisting of 2,3-dihydroxypropyl oleate (glyceryl monooleate) and medium-chain triglycerides with tunable internal… CONTINUE READING