Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway

@inproceedings{Ren2017CitrateST,
  title={Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway},
  author={Jian-Guo Ren and Pankaj Seth and Huihui Ye and Kun Guo and Jun-ichi Hanai and Zaheed Husain and Vikas P Sukhatme},
  booktitle={Scientific Reports},
  year={2017}
}
In this study we have tested the efficacy of citrate therapy in various cancer models. We found that citrate administration inhibited A549 lung cancer growth and additional benefit accrued in combination with cisplatin. Interestingly, citrate regressed Ras-driven lung tumors. Further studies indicated that citrate induced tumor cell differentiation. Additionally, citrate treated tumor samples showed significantly higher infiltrating T-cells and increased blood levels of numerous cytokines… CONTINUE READING
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