Citrate--new functions for an old metabolite.

@article{Iacobazzi2014CitratenewFF,
  title={Citrate--new functions for an old metabolite.},
  author={Vito Iacobazzi and Vittoria Infantino},
  journal={Biological chemistry},
  year={2014},
  volume={395 4},
  pages={
          387-99
        }
}
Citrate is an important substrate in cellular energy metabolism. It is produced in the mitochondria and used in the Krebs cycle or released into cytoplasm through a specific mitochondrial carrier, CIC. In the cytosol, citrate and its derivatives, acetyl-CoA and oxaloacetate, are used in normal and pathological processes. Beyond the classical role as metabolic regulator, recent studies have highlighted that citrate is involved in inflammation, cancer, insulin secretion, histone acetylation… CONTINUE READING

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