Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3.

@article{Thomas2016CitralRB,
  title={Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3.},
  author={Margaret Lois Thomas and Roberto de Antueno and Krysta Mila Coyle and Mohammad Sultan and Brianne Marie Cruickshank and Michael Anthony Giacomantonio and Carman Anthony Giacomantonio and Roy Duncan and Paola Marcato},
  journal={Molecular oncology},
  year={2016},
  volume={10 9},
  pages={1485-1496}
}
Breast cancer stem cells (CSCs) can be identified by increased Aldefluor fluorescence caused by increased expression of aldehyde dehydrogenase 1A3 (ALDH1A3), as well as ALDH1A1 and ALDH2. In addition to being a CSC marker, ALDH1A3 regulates gene expression via retinoic acid (RA) signaling and plays a key role in the progression and chemotherapy resistance of cancer. Therefore, ALDH1A3 represents a druggable anti-cancer target of interest. Since to date, there are no characterized ALDH1A3… CONTINUE READING
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