Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression.

  title={Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression.},
  author={Michiko Katsukawa and Rieko Nakata and Yoshie Takizawa and Kazuyuki Hori and Saori Takahashi and Hiroyasu Inoue},
  journal={Biochimica et biophysica acta},
  volume={1801 11},
Lemongrass is a widely used herb as a food flavoring, as a perfume, and for its analgesic and anti-inflammatory purposes; however, the molecular mechanisms of these effects have not been elucidated. Previously, we identified carvacrol from the essential oil of thyme as a suppressor of cyclooxygenase (COX)-2, a key enzyme for prostaglandin synthesis, and also an activator of peroxisome proliferator-activated receptor (PPAR), a molecular target for "lifestyle-related" diseases. In this study, we… CONTINUE READING
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