Corpus ID: 178774950

Citocromo P-450 y función vascular

  title={Citocromo P-450 y funci{\'o}n vascular},
  author={D. P. Ocejo and A. G. Sacrist{\'a}n},


Characterization of an apamin‐sensitive small‐conductance Ca2+‐activated K+ channel in porcine coronary artery endothelium: relevance to EDHF
The porcine coronary artery endothelium expresses an apamin‐sensitive SKCa containing the SK3 subunit, which is likely to confer all or part of the apamin•sensitive component of the endothelia‐derived hyperpolarizing factor (EDHF) response. Expand
Dynamic Modulation of Interendothelial Gap Junctional Communication by 11,12-Epoxyeicosatrienoic Acid
It is demonstrated that an agonist-activated CYP-dependent pathway as well as 11,12-EET can positively regulate interendothelial gap junctional communication, most probably via the activation of PKA, an effect that is curtailed by the subsequent activation of ERK1/2. Expand
EDHF: bringing the concepts together.
Several mechanisms have been proposed to link this pivotal step to the subsequent smooth muscle hyperpolarization and the main concepts are considered in detail in this review. Expand
Endothelium-Derived Hyperpolarizing Factor Synthase (Cytochrome P450 2C9) Is a Functionally Significant Source of Reactive Oxygen Species in Coronary Arteries
The results suggest that a CYP isozyme homologous to CYP 2C9 is a physiologically relevant generator of ROS in coronary endothelial cells and modulates both vascular tone and homeostasis. Expand
Epoxyeicosatrienoic Acid–Mediated Renal Vasodilation to Arachidonic Acid Is Enhanced in SHR
The hypothesis that cyclooxygenase-independent vasodilation produced by arachidonic acid (AA) is mediated by epoxyeicosatrienoic acids (EETs) and is blunted in the spontaneously hypertensive rat (SHR) was tested and the demonstration that AA greatly enhanced the renal efflux of EETs at high PP but not at basal PP was supported. Expand
Epoxygenase Metabolites Contribute to Nitric Oxide-Independent Afferent Arteriolar Vasodilation in Response to Bradykinin
The concept that EETs are EDHFs and contribute to the nitric oxide-independent afferent arteriolar vasodilation elicited by bradykinin is supported. Expand
Microsomal monooxygenase in apoptosis: another target for cytochrome c signaling?
  • D. Davydov
  • Biology, Medicine
  • Trends in biochemical sciences
  • 2001
The theory that microsomal cytochrome b(5), which modulates the production of ROS in MMO, is among the principal interacting targets of cyt c and the role of this interaction in the initiation of apoptosis is discussed. Expand
Regulation of cyclooxygenase-2 expression by nitric oxide in cells.
The capacity of NO and its effector cyclic GMP to modulate the function of several target proteins, including transcription factors such as nuclear factor-kappaB and activator protein-1, appears as the key pathway by which NO may regulate COX-2 expression. Expand
The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells
Observations indicate that EDHF/11,12-EET is not simply a vasodilator and that its continuous release under pulsatile conditions in vivo may affect vascular cell signalling and proliferation. Expand
normal pressure - natriuresis in hypertension : role of cytochrome P - 450 metabolites of arachidonic acid
  • Am . J . Hypertens .
  • 2001