Citius, Altius, Fortius: The New Paradigm in the Treatment of Chronic Hepatitis C Disease

@article{Abraham2018CitiusAF,
  title={Citius, Altius, Fortius: The New Paradigm in the Treatment of Chronic Hepatitis C Disease},
  author={George M. Abraham and Linda M. Spooner},
  journal={Clinical Infectious Diseases},
  year={2018},
  volume={66},
  pages={464–474}
}
With the advent of the direct-acting antiviral agents (DAAs) for chronic hepatitis C infection, the treatment paradigm has dramatically changed, especially the duration, tolerability, and response to therapy. The DAAs fall into several classes and are variously indicated in the treatment of one or more genotypes of infection. All these agents are orally administered and, as they are largely renally eliminated (with exceptions), do not require adjustment in mild to moderate renal insufficiency… 

Tables from this paper

World Health Organization Guidelines on Treatment of Hepatitis C Virus Infection: Best Practice Advice From the American College of Physicians
TLDR
The World Health Organization updated its evidencebased guideline on chronic HCV infection in July 2018 and recommendations are relevant to the United States, where equity and resource allocation issues are also important considerations.

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