Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)

@article{Dvalos2012CiticolineIT,
  title={Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)},
  author={Antoni D{\'a}valos and Jos{\'e} {\'A}lvarez-Sab{\'i}n and Jos{\'e} Castillo and Exuperio D{\'i}ez-Tejedor and Jos{\'e} M. Ferro and Eduardo Martı́nez-Vila and Joaqu{\'i}n Serena and Tom{\'a}s Segura and V{\'i}tor Tedim Cruz and Jaime Masju{\'a}n and Erik Cobo and Julio J Secades},
  journal={The Lancet},
  year={2012},
  volume={380},
  pages={349-357}
}

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This study suggests that oral citicoline can be used safely with minimal side effects in acute stroke treatment and appears to improve functional outcome and reduce neurologic deficit with 500 mg ofciticoline appearing to be the optimal dose.

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Citicoline was safe but ineffective in improving the outcome of patients with acute ischemic stroke who were enrolled in this trial, and post hoc analyses indicate that there may be a subgroup of Patients with moderate to severe strokes who would benefit.

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Treatment with oral citicoline within the first 24 hours after onset in patients with moderate to severe stroke increases the probability of complete recovery at 3 months, and the overall safety ofciticoline was similar to placebo.

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