Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia

@article{Adibhatla2003CiticolineDP,
  title={Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia},
  author={Rao Muralikrishna Adibhatla and James Franklin Hatcher},
  journal={Journal of Neuroscience Research},
  year={2003},
  volume={73}
}
Neuroprotection by citicoline (CDP‐choline) in transient cerebral ischemia has been demonstrated previously. Citicoline has undergone several Phase III clinical trials for stroke, and is being evaluated for treatment of Alzheimer's and Parkinson's diseases. Phospholipid degradation and generation of reactive oxygen species (ROS) are major factors causing neuronal injury in CNS trauma and neurodegenerative diseases. Oxidative metabolism of arachidonic acid (released by the action of… Expand
Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia.
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Cytidine‐5'‐Diphosphocholine Protects the Liver From Ischemia/Reperfusion Injury Preserving Mitochondrial Function and Reducing Oxidative Stress
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Phospholipase A2, hydroxyl radicals, and lipid peroxidation in transient cerebral ischemia.
TLDR
Results suggest that citicoline provides neuroprotection by attenuating the stimulation of PLA2, the predominant isoform in membrane and mitochondria. Expand
Phospholipase A 2 , Hydroxyl Radicals , and Lipid Peroxidation in Transient Cerebral Ischemia
Phospholipid degradation is an important promoter of neuronal death after transient cerebral ischemia. Phospholipid hydrolysis by phospholipase A2 (PLA2) after transient cerebral ischemia releasesExpand
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TLDR
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TLDR
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