Citicoline Inhibits MAP Kinase Signalling Pathways after Focal Cerebral Ischaemia

@article{Krupinski2005CiticolineIM,
  title={Citicoline Inhibits MAP Kinase Signalling Pathways after Focal Cerebral Ischaemia},
  author={John Krupinski and Mark Slevin and L Badimon},
  journal={Neurochemical Research},
  year={2005},
  volume={30},
  pages={1067-1073}
}
The link between membrane phospholipids and different intracellular signal transduction pathways affected by cerebral ischaemia is unclear. CDP-choline, a major neuronal membrane lipid precursor and its intracellular target proteins and transcription factors were studied to further understand its role in ischaemic stroke. Cerebral ischaemia was produced by distal, permanent occlusion of the middle cerebral artery (MCAO) in the rat. Animals receiving 500 mg/kg of CDP-choline in 0.5 ml of 0.9… CONTINUE READING