Citalopram for post-stroke pathological crying

  title={Citalopram for post-stroke pathological crying},
  author={Grethe Andersen and Karsten Vestergaard and Jens {\O}stergaard Riis},
  journal={The Lancet},

Paroxetine versus citalopram treatment of pathological crying after brain injury.

Rap onset (within 1-3 days) and highly significant (p < 0.001) improvements of emotionalism were observed after both paroxetine and citalopram, and there were no efficacy differences, despite the longer symptom duration in the cITALopram group.

Post‐stroke pathological crying: frequency and correlation to depression

Post‐stroke pathological crying was common and persistent in 11% of patients at 1 year and correlated strongly to mood score and post‐stroke depression, and the indication for treatment of pathological crying is further strengthened.

Lamotrigine treatment for post-stroke pathological laughing and crying.

A 60-year-old woman developed PLC after an ischemic stroke and was treated with lamotrigine initially at the dose of 50mg a day, which was gradually increased to 100 mg a day over a 4-week period, showing a significant and rapid recovery in both laughing and crying components of PCL with lamOTrigine treatment.

Prediction of the response to citalopram and reboxetine in post-stroke depressed patients

Citalopram or other SSRIs and reboxetine may be of first choice treatment in PSD because of their good efficacy and lack of severe side effects.

Effectiveness of quetiapine for poststroke pathological laughing: case report and review of the literature.

A 42-year-old man who developed PL 4 weeks after a hemorrhage stroke affecting the paramedian pons is demonstrated, demonstrating the beneficial effect of quetiapine, an atypical antipsychotic agent with enhancing serotonergic neurotransmitter activity, in a patient with post-stroke PL.

Mirtazapine treatment for pathological laughing and crying after stroke.

This is one of the first reports to suggest that mirtazapine may be an alternative to SSRIs for treating poststroke PLC, and both the laughing and crying spells of a 64-year-old woman were improved within a few days of mirtzapine administration.

Treatment of Uncontrolled Crying After Stroke

The present treatment possibilities can significantly improve quality of life for patients with post-stroke pathological crying, and there seems to be a rationale for the latter approach.

Fluoxetine Treatment in Poststroke Depression, Emotional Incontinence, and Anger Proneness: A Double-Blind, Placebo-Controlled Study

Fluoxetine significantly improved PSEI and PSAP, whereas no definitive improvement of PSD was found and its effect on PSD is not solidly confirmed.

Post-Stroke depression and pathological crying: Clinical aspects and new pharmacological approaches

The aetiology of post-stroke depression seems to involve mainly organic but also non-organic factors, although no single factor has been identified which is able to explain the majority of cases.

Pathological crying and laughing: treatment with sertraline.




Treatment of pathologic laughing and weeping with amitriptyline.

It is concluded that amitriptyline is effective in the treatment of this disturbance of affective expression, and that this effect is distinct from the antidepressant effect of the medication.

Emotionalism after stroke.

Emotionalism is common after stroke and is associated with symptoms of a more general mood disturbance and is found especially in patients with left frontal and temporal lesions.

Pathologic laughing and crying treated with levodopa.

Because part of pathologic laughing and crying seems to be caused by the decreased function of the dopaminergic neuron, levodopa or amantadine is worth trying.

The Use of Imipramine (“Tofranil”) and Other Psychotropic Drugs in Organic Emotionalism

A “double-blind” form of therapeutic trial was engaged, comparing two dose strengths of imipramine with phenobarbitone and dummy tablets given in random sequence to each patient, confirming the favourable impression of imIPramine being confirmed and attempting to assess the effect on this symptom of two other drugs of related pharmacology.

Pathological Display of Affect in Patients with Depression and Right Frontal Brain Damage: An Alternative Mechanism

The cases argue that two organic brain diseases—one structural and the other “physiopharmacological”—may interact to produce pathological display of affect that cannot be accounted for by traditional neurological explanations, and suggest that pathological affect is a valuable clinical indicator of an underlying major depression in some brain-injured patients.


  • M. Hamilton
  • Psychology, Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1960
The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.

Emotionalism following brain damage: a complex phenomenon.

In future research each component of emotionalism should be examined in detail using a standardized form of assessment.

An activities index for use with stroke patients.

Factor analysis indicates three major factors (domestic chores, leisure/work, outdoor activities) are sex-linked, as predicted, and some evidence is noted of the sensitivity of the index to severity of stroke.