Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trial.

@article{Zisook2009CitalopramAF,
  title={Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trial.},
  author={Sidney Zisook and John W. Kasckow and Shahrokh Golshan and Ian Fellows and Ellen Solorzano and David Lehman and Somaia Mohamed and Dilip V. Jeste},
  journal={The Journal of clinical psychiatry},
  year={2009},
  volume={70 4},
  pages={562-71}
}
BACKGROUND Subsyndromal symptoms of depression (SSD) in older outpatients with schizophrenia are common and clinically important. While many physicians prescribe antidepressants to patients with schizophrenia and schizoaffective disorder who have SSD, evidence for their effectiveness and safety has been meager. We describe a randomized placebo-controlled trial of citalopram in 198 patients. METHOD Participants in this 2-site study, conducted from September 1, 2001, to August 31, 2007, were… CONTINUE READING

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