Citalopram amplifies the influence of living conditions on mood in depressed patients enrolled in the STAR*D study

@article{Chiarotti2017CitalopramAT,
  title={Citalopram amplifies the influence of living conditions on mood in depressed patients enrolled in the STAR*D study},
  author={Flavia Chiarotti and Aurelia Viglione and Alessandro Giuliani and Igor Branchi},
  journal={Translational Psychiatry},
  year={2017},
  volume={7}
}
Selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressant drugs, have a variable and incomplete efficacy. In order to better understand SSRI action, we explored the hypothesis that SSRIs do not affect mood per se but amplify the influence of the living conditions on mood. To this aim, we exploited the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) data set, selected a subpopulation of 591 patients with an overlapping clinical history and… 

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References

SHOWING 1-10 OF 28 REFERENCES

Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment

TLDR
The hypothesis positing that SSRIs may not affect mood per se but, by enhancing neural plasticity, render the individual more susceptible to the influence of the environment is explored, suggesting that SSRI administration in a favorable environment promotes a reduction of symptoms, whereas in a stressful environment leads to a worse prognosis.

Sociodemographic Predictors of Response to Antidepressant Treatment

TLDR
The degree of improvement in psychosocial functioning observed in depressed outpatients following antidepressant treatment appears to be related to the level of education at study entry, but not to other sociodemographic variables.

Antidepressant Treatment Outcome Depends on the Quality of the Living Environment: A Pre-Clinical Investigation in Mice

TLDR
The findings suggest that the effect of SSRI on depression-like phenotypes in mice is not determined by theDrug per se but is induced by the drug and driven by the environment, which may be helpful to explain variable effects ofSSRI found in clinical practice and to device strategies aimed at enhancing their efficacy by means of controlling environmental conditions.

PREDICTORS OF RESPONSE TO AMITRIPTYLINE AND PLACEBO IN THREE OUTPATIENT TREATMENT SETTINGS

The present report examines the predictors and modifiers of response to amitriptyline in an effort to: identify variables whose effects on drug response are general enough to apply to a range of

The STAR*D project results: A comprehensive review of findings

TLDR
Prognosis was better at all levels for participants who entered follow-up in remission as opposed to those who entered with response without remission, highlighting the prevalence of treatment-resistant depression and suggesting potential benefit for using more vigorous treatments in the earlier steps.

Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study.

Outcome of anxiety and depressive disorders in primary care

TLDR
This naturalistic study helps to provide a framework for further studies with more precisely defined groups of people with depression and an effective treatment strategy for people with marked depression and ongoing social difficulties is especially needed.