Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory Effects.

@article{Kadiyala2016CistromebasedCB,
  title={Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory Effects.},
  author={Vineela Kadiyala and Sarah K Sasse and Mohammed O Altonsy and Reena L Berman and Hong Wei Chu and Tzu L. Phang and Anthony N Gerber},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 24},
  pages={12673-87}
}
Antagonism of pro-inflammatory transcription factors by monomeric glucocorticoid receptor (GR) has long been viewed as central to glucocorticoid (GC) efficacy. However, the mechanisms and targets through which GCs exert therapeutic effects in diseases such as asthma remain incompletely understood. We previously defined a surprising cooperative interaction between GR and NF-κB that enhanced expression of A20 (TNFAIP3), a potent inhibitor of NF-κB. Here we extend this observation to establish… CONTINUE READING