Cisternal sustained release dihydropyridines for subarachnoid hemorrhage.

@article{Cook2012CisternalSR,
  title={Cisternal sustained release dihydropyridines for subarachnoid hemorrhage.},
  author={Douglas J. Cook and Sabrina Kan and Jinglu Ai and Hidetoshi Kasuya and Robert L Macdonald},
  journal={Current neurovascular research},
  year={2012},
  volume={9 2},
  pages={
          139-48
        }
}
Nimodipine improved outcome in patients with subarachnoid hemorrhage (SAH) although hypotension limited the dose that could be administered systemically. Subarachnoid delivery of nicardipine or nimodipine may be more efficacious. We tested the efficacy of cisternal application of sustained release nicardipine and nimodipine in SAH in monkeys and dogs, respectively. SAH was created in 13 cynomolgus macaques by placement of autologous blood clot around right middle cerebral, anterior cerebral… CONTINUE READING
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