Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury.

@article{Jung2009CisplatinUM,
  title={Cisplatin upregulates mitochondrial nitric oxide synthase and peroxynitrite formation to promote renal injury.},
  author={Michaela Jung and Georgina Hotter and Jose Luis Vi{\~n}as and Anna Sola},
  journal={Toxicology and applied pharmacology},
  year={2009},
  volume={234 2},
  pages={236-46}
}
The mitochondria are a critical target for cisplatin-associated nephrotoxicity. Though nitric oxide formation has been implicated in the toxicity of cisplatin, this formation has not so far been related to a possible activation of mitochondrial nitric oxide synthase (mNOS). We show here that the upregulation of oxide mNOS and peroxynitrite formation in cisplatin treatment are key events that influence the development of the harmful parameters described in cisplatin-associated kidney failure. We… CONTINUE READING

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