Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family.

  title={Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family.},
  author={Lynn M. Pouliot and Yu-Chi Chen and J. T. Ramani Bai and Rajarashi Guha and Scott E. Martin and Michael M. Gottesman and Matthew D. Hall},
  journal={Cancer research},
  volume={72 22},
Resistance to platinum-based therapies arises by multiple mechanisms, including by alterations to cell-cycle kinases that mediate G(2)-M phase arrest. In this study, we conducted parallel high-throughput screens for microRNAs (miRNA) that could restore sensitivity to cisplatin-resistant cells, and we screened for kinases targeted by miRNAs that mediated cisplatin resistance. Overexpression of the cell-cycle kinases WEE1 and CHK1 occurred commonly in cisplatin-resistant cells. miRNAs in the miR… CONTINUE READING

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The mechanism of action of cisplatin: from adducts to apoptosis. In:Lippert B, editor. Cisplatin: chemistry and biochemistry of a leading anticancer drug

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