Cisplatin protein binding in pregnancy and the neonatal period.

  title={Cisplatin protein binding in pregnancy and the neonatal period.},
  author={D M Zemlickis and Jared Klein and G M Moselhy and Gideon Koren},
  journal={Medical and pediatric oncology},
  volume={23 6},
The most effective combination regimes for ovarian cancer contain cisplatin, but there is little knowledge about cisplatin use during pregnancy. The high protein binding of cisplatin means that small changes in protein binding result in large changes in the fraction of free drug. It is the free form of cisplatin that crosses the placenta and may contribute to fetal toxicity. The purpose of the present study was to compare protein binding of cisplatin in pregnant women, non-pregnant women, and… CONTINUE READING