Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients.

@article{Yoo2014CisplatinOU,
  title={Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients.},
  author={John Yoo and Scott J Hamilton and Douglas Angel and Kevin M.T. Fung and Jason Franklin and Lorne S. Parnes and Denise Y. Lewis and Varagur Mohan Venkatesan and Eric William Winquist},
  journal={The Laryngoscope},
  year={2014},
  volume={124 3},
  pages={
          E87-94
        }
}
OBJECTIVES/HYPOTHESIS To evaluate the feasibility and efficacy of transtympanic L-N-Acetylcysteine (L-NAC) administration in patients receiving cisplatin chemotherapy for head and neck cancer. STUDY DESIGN Prospective randomized nonblinded open-label clinical trial. METHODS Transtympanic 2% L-NAC was administered to one randomly selected ear with the other ear as control in each patient. Primary outcome parameter was the difference in the loss of pure tone averages (PTA) at 2, 4, and 8 kHz… CONTINUE READING
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