Cisplatin nephrotoxicity.

  title={Cisplatin nephrotoxicity.},
  author={Istvan Arany and Robert L. Safirstein},
  journal={Seminars in nephrology},
  volume={23 5},
Cisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeated exposure. The kidney accumulates cisplatin to a higher degree than other organs perhaps via mediated transport. Functionally, reduced renal perfusion and a concentrating defect characterize its nephrotoxicity, whereas morphologically necrosis of the terminal portion of the proximal tubule and… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 263 extracted citations

Similar Papers

Loading similar papers…