Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.

@article{Garca2012CisplatinIT,
  title={Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.},
  author={Mercedes Mori Sequeiros Garc{\'i}a and Andrea B Acquier and Guadalupe Su{\'a}rez and Natalia V G{\'o}mez and Alejandra Beatriz Gorostizaga and Carlos F. Mendez and Cristina Paz},
  journal={Chemico-biological interactions},
  year={2012},
  volume={199 3},
  pages={185-91}
}
Cisplatin (Cs) is a chemotherapeutic agent able to generate reactive oxygen species (ROS) which are linked to several side effects of the drug. Even when it is known that Cs produces Leydig cell dysfunction, it is unknown whether this particular side effect is mediated by ROS. The aim of this study was to evaluate the in vitro effects of Cs on testosterone production and the participation of ROS in this effect. We demonstrate that Cs promotes the generation of ROS in a time-, and concentration… CONTINUE READING

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