Cisplatin-induced post-translational modification of histones H3 and H4.

  title={Cisplatin-induced post-translational modification of histones H3 and H4.},
  author={Dong Wang and Stephen J Lippard},
  journal={The Journal of biological chemistry},
  volume={279 20},
The anti-cancer drug cisplatin kills cells by damaging DNA and inducing apoptosis. Understanding the detailed mechanisms by which cancer cells respond to cisplatin has the potential to improve substantially platinum-based therapy. Post-translational modification of histones alters chromatin structure, facilitating the binding of nuclear factors that mediate DNA repair, transcription, and other processes. In the present study, we have investigated the effects of cisplatin treatment on histone… CONTINUE READING
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