Cisplatin-induced pica behaviour in rats is prevented by antioxidants with antiemetic activity.


Pica, eating of non-nutritive substances such as kaolin in rats has been suggested as an illness response behaviour, analogous to vomiting in species that have developed emetic reflex. We have recently demonstrated that antioxidants-glutathione, N-(2- mercaptopropionyl)glycine (tiopronin), vitamin C and vitamin E-exert antiemetic effect against cisplatin… (More)