Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice.

  title={Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice.},
  author={Pragati Sawhney and C John Giammona and Marvin L. Meistrich and John H. Richburg},
  journal={Journal of andrology},
  volume={26 1},
Exposure to cisplatin results in impaired spermatogenesis, azoospermia, and, sometimes, permanent infertility in male patients. The mechanism(s) by which cisplatin induces damage to testicular cells is poorly understood. We previously reported that acute exposure to cisplatin results in elevated germ cell apoptotic rates and that this indicates long-term damage to the seminiferous epithelium. Here, we present data that implicate an injury to Sertoli cells as a possible mechanism to explain an… CONTINUE READING
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