Cisplatin-induced kidney injury in the rat: L-carnitine modulates the relationship between MMP-9 and TIMP-3.

@article{Martinez2009CisplatininducedKI,
  title={Cisplatin-induced kidney injury in the rat: L-carnitine modulates the relationship between MMP-9 and TIMP-3.},
  author={Giuseppa Martinez and Giuseppe Costantino and Anna Clementi and Michele Puglia and Silvia Clementi and Giuseppina Cantarella and Leonardo De Meo and Mario Matera},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2009},
  volume={61 3},
  pages={183-8}
}
Renal interstitial fibrosis is a major complication of cisplatin treatment, due to the increased accumulation of extracellular matrix (ECM) proteins whose remodeling is important for the development of normal tissues; indeed, its malfunction might play a role in the etiology of various diseases. Biopharmacological evaluations suggest that L-carnitine can prevent cardiac metabolic damage caused by doxorubicin, as well as can inhibit cisplatin-induced injury in the kidney and in the small… CONTINUE READING
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