Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea.

  title={Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea.},
  author={S. M. Didar Al Alam and Katsuhisa Ikeda and Takeshi Oshima and Mitsuya Kato Katsufumi Watahiki Tatsuyuki Suzuki and Tetsuaki Kawase and Toshihiko Kikuchi and Tomonori Takasaka},
  journal={Hearing research},
  volume={141 1-2},
Cisplatin is well known to cause cochleotoxicity. In order to determine the underlying mechanisms of cisplatin-induced cell death in the cochlea, we investigated the apoptotic changes and the expression of bcl-2 family proteins controlling apoptosis. Mongolian gerbils were administered 4 mg/kg/day cisplatin consecutively for 5 days. The cisplatin-treated animals showed a significant deterioration in the responses of both distortion product otoacoustic emissions and the endocochlear potential as… CONTINUE READING


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