Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies

Abstract

Cisplatin is one of the most widely used and highly effective drug for the treatment of various solid tumors; however, it has dose-dependent side effects on the kidney, cochlear, and nerves. Nephrotoxicity is the most well-known and clinically important toxicity. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory responses, are closely associated with cisplatin-induced nephrotoxicity. Even though the establishment of cisplatin-induced nephrotoxicity can be alleviated by diuretics and pre-hydration of patients, the prevalence of cisplatin nephrotoxicity is still high, occurring in approximately one-third of patients who have undergone cisplatin therapy. Therefore it is imperative to develop treatments that will ameliorate cisplatin-nephrotoxicity. In this review, we discuss the mechanisms of cisplatin-induced renal toxicity and the new strategies for protecting the kidneys from the toxic effects without lowering the tumoricidal activity.

DOI: 10.5049/EBP.2014.12.2.55

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@inproceedings{Oh2014CisplatininducedKD, title={Cisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment Strategies}, author={Gi-Su Oh and Hyung-jin Kim and Aihua Shen and Su Bin Lee and Dipendra Khadka and Arpana Pandit and Hong-Seob So}, booktitle={Electrolyte & blood pressure : E & BP}, year={2014} }