Cisplatin incorporated in microspheres: development and fundamental studies for its clinical application.

@article{Fujiyama2003CisplatinII,
  title={Cisplatin incorporated in microspheres: development and fundamental studies for its clinical application.},
  author={Junshin Fujiyama and Yuen Nakase and Kimihiko Osaki and Chouhei Sakakura and Hisakazu Yamagishi and Akeo Hagiwara},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2003},
  volume={89 3},
  pages={397-408}
}
A new drug delivery formulation, biodegradable glycolic acid-lactic acid copolymer (PGLA) microspheres incorporating cisplatin (CDDP-MS) has been developed for the treatment of peritoneal carcinomatosis. Scanning electron microscopy showed that CDDP-MS has a smooth surface and few cisplatin crystals in the hollow. An electron probe micro analyzer revealed that cisplatin was located mainly in the matrix in the state of a molecule. Release profile in vitro of CDDP from microspheres showed that… CONTINUE READING

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